Preliminary studies on the inhibition of D-sorbitol-6-phosphate 2–dehydrogenase fromEscherichia coliwith substrate analogues
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چکیده
منابع مشابه
D-sorbitol-6-phosphate dehydrogenase from Lactobacillus casei.
Several different systems for the conversion of sorbitol to hexose have been described in microorganisms. In the pseudomonads, sorbitol may be oxidized to fructose (Shaw, 1956) or to sorbose (Sebek and Randles, 1952). The latter investigators concluded that the conversion of sorbitol to fructose or sorbose did not involve phosphorylation since carbon dioxide was not liberated from bicarbonate b...
متن کاملD-Mannitol 1-phosphate dehydrogenase and D-sorbitol 6-phosphate dehydrogenase in Aerobacter aerogenes.
n-Mannitol has been used as a carbon source for the growth of many microorganisms. Some bacteria contain diphosphopyridine nucleotide-dependent dehydrogenases that will oxidize n-mannitol to n-fructose at the nonphosphorylated level (2-5). On the other hand, Wolff and Kaplan (6, 7) have reported the presence of a diphosphopyridine nucleotide-dependent n-mannitol l-phosphate dehydrogenase that o...
متن کاملD-Mannitol l-Phosphate Dehydrogenase and D-Sorbitol 6-Phosphate Dehydrogenase in Aerobacter aerogenes”
n-Mannitol has been used as a carbon source for the growth of many microorganisms. Some bacteria contain diphosphopyridine nucleotide-dependent dehydrogenases that will oxidize n-mannitol to n-fructose at the nonphosphorylated level (2-5). On the other hand, Wolff and Kaplan (6, 7) have reported the presence of a diphosphopyridine nucleotide-dependent n-mannitol l-phosphate dehydrogenase that o...
متن کاملStudies on the interaction of aldolase with substrate analogues.
Interactions of specific and nonspecific agents at the dihydroxyacetone-P and glyceraldehyde-3-P sites of rabbit muscle aldolase are shown by several methods: quenching of protein fluorescence, protection against the destructive action of trypsin, the inhibition of initial rates and of equilibrium exchange rates, and the inactivation caused by NaBH4. It is concluded from inactivation and labeli...
متن کاملStudies on alkaline phosphatase. Inhibition by phosphate derivatives and the substrate specificity.
1. The kinetics of inhibition of calf-intestinal alkaline phosphatase by inorganic phosphate, fluorophosphate, inorganic pyrophosphate, beta-glycerophosphate and adenosine 5'-triphosphate in the range pH8-10 were investigated. The reference substrate was 4-methylumbelliferyl phosphate. 2. The inhibitions were ;mixed' in that both K(m) and V were affected, but the competitive element was by far ...
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ژورنال
عنوان ژورنال: Journal of Enzyme Inhibition and Medicinal Chemistry
سال: 2006
ISSN: 1475-6366,1475-6374
DOI: 10.1080/14756360500535260